Medicatie en drugs die Serotonine syndroom kunnen veroorzaken:
- Antidepressiva: MAOI's, TCA's, SSRI's, SNRI's, bupropion, nefazodone, trazodone, mirtazapine, tapentadol
- Opioids: Tramadol, pethidine, fentanyl, pentazocine, buprenorphine,
- CNS stimulanten: MDMA, MDA, -, diethylpropion, amfetamine, sibrutramine, methylphenidate, methamfetamine en cocaïne.
- 5-HT1 agonisten: Triptans
- Psychedelica: Foxy(5-MeO-DiPT) en LSD
- Kruiden: St. Janskruid, Syrian Rue, Panax ginseng, Nutmeg, Yohimbe
- Anderen: tryptophan, L-Dopa, valproate, buspirone, lithium, linezolid, dextromethorphan, 5-hydroxytryptophan, chlorpheniramine, risperidone, olanzapine, ondansetron, granisetron, metoclopramide, ritonavir