Ik gebruik voor jullie even mijn uni account om eens wat recente onderzoeken te vinden
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Ik heb geen zin in de onderzoeken zelf te gaan lezen dus bij deze de abstracts. Behalve deze drie kan ik wel een en ander vinden, maar vrij weinig over de specifieke combinatie en de werking daarvan op het lichaam.
Deze uit 1980 op muizen, maar stond bovenaan mijn zoekopdracht:
Four benzodiazepine tranquilizers have been tested, alone or in combination with amphetamine, on spontaneous locomotor activity of C57BL/6 mice. Amphetamine-induced locomotor stimulation was enhanced by chlordiazepoxide, diazepam, and medazepam, but not by bromazepam. The results indicate that benzodiazepine derivatives may be somewhat differentiated on the basis of their interactions with amphetamine.
Deze is uit 2014:
The impairing effects of combined use of amphetamines and benzodiazepines among recreational drug users are not well described, but knowledge about this is important in the risk assessment of such combined drug use. The aim of this study was to compare the impairment, among apprehended drivers, as judged by a clinical test of impairment (CTI), in cases where a combination of amphetamines and benzodiazepines was detected, in blood, with cases where only one of the two drug groups was detected.
The results of CTI judgments were compared to toxicological drug tests of blood samples that were obtained at the time of CTI screening in cases containing amphetamines only, cases containing different benzodiazepines only, and cases containing a combination of amphetamines and benzodiazepines.
There were significantly more drivers being judged as impaired in the combined group (n = 777), compared both with amphetamines alone (n = 267, χ2 = 47.8, p < 0.001) and benzodiazepines alone (n = 153, χ2 = 7.0, p = 0.00
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. This was also seen when only including the lowest concentrations of benzodiazepines (χ2 = 4.3, p = 0.03
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. The concentrations of the drugs were higher in the single drug groups, compared with the combined group.
This study indicates that during real-life driving, those influenced by both amphetamines and benzodiazepines are more impaired, as judged by the CTI, compared with those influenced by either drug alone, although the combined group showed lower drug concentrations.