Diphenhydramine... The drug everyone looks away from. For most people, it's either an actively terrible experience or just a very strange one. Everywhere you look online for information about it, the reports are pretty uniform: I felt like shit, saw spiders everywhere, and you shouldn't do it. My report below is pretty similar, but I tried to put as much helpful information in it as I could. This drug was the first "real drug" I ever did, besides smoking weed once or twice beforehand, and it's influenced my life quite a bit. Not in a good way, though. I'm relatively experienced with this substance, but if I got anything wrong, please let me know and I'll edit it. Most of the information I have here is from my own mind, gathered through reading dozens of forum/reddit posts about it, abusing it for a period, and reading various studies and case reports about it. If you'd like a source or clarification for any information, let me know and I will do my best to give it to you.
Safety:
PLEASE READ THIS. This is important to know, as DPH is probably one of the most damaging yet easily available drugs when it comes to your health.
There is no truly safe dose of DPH,
especially if you take it repeatedly, since the mechanisms that cause the DPH high are the same mechanisms that cause health problems associated with its use.
Even 25-50 mg doses have been linked to an increased rate of dementia later in life. DPH is hell on your liver and kidneys, much like acetaminophen/Tylenol, and repeat users often complain of organ pains, especially in the kidneys. This is exacerbated by DPHâs addictive nature. Even people who hate the diphenhydramine experience may still, for some reason, feel compelled to use it. Also of note are reports of erectile dysfunction after using DPH for fap doses.
The potential health complications are myriad, including restless legs syndrome, brain damage, tachycardia, seizures, serotonin syndrome, heart attacks, stroke, cardiac arrhythmia, psychosis, hallucinogen persisting perception disorder, depression, erectile dysfunction, and death. These become much more likely if DPH is used regularly and/or in high doses. Those under 18 should especially be wary of DPH, as it almost certainly causes brain damage, especially if the brain is still forming.
Pharmacology: Diphenhydramine has several receptor targets. It is an anticholinergic, blocking the action of the neurotransmitter acetylcholine, which is where the majority of its deliriant effects come from. DPH is also a selective serotonin reuptake inhibitor (SSRI), as well as being an inverse agonist at the histamine receptors, which is where its anti-allergy effects come from. Especially at higher doses, DPH also inhibits sodium and potassium channels in the heart, which can lead to torsades de pointes, cardiac arrhythmia, and heart attack. Stay away from this drug if you have any sort of cardiovascular issues.
Addiction: It's true that DPH is not fun for the vast majority of those who try it. Some rare people, such as myself, do get some measure of "fun" or "euphoria" from it (this faded quickly after my first few trips), but this is not true for most people. However...despite how absolutely shitty the trip is, quite a few people feel an urge to take it again. For me, it was a thought like
"If I take it again tomorrow night, maybe the trip won't be as bad this time!". My advice to prevent binges on it due to this strange effect would be to make a schedule for dosing and stick to it, and don't trip on a whim. This is a toxic substance and it can get out of hand quite fast.
Dosage: Take these dosages with a grain of salt. Depending on the person, different dosages can have huge differences in effects. It seems to be at least partly based on body weight. A close friend of mine whoâs a bigger guy(Iâd guess around 225 pounds) took ~900 milligrams and it had about the same effect on him as 250 mg did on me, a 145 pound male. Another friend, right around 100 lbs in weight, took about 250 mg and saw shadow people.
I specify benadryl pills because they are the most common way of ingesting DPH. Each one is 25 milligrams. Some other brands are 50 mg, so make sure you know what each pill for your brand is dosed at. DPH syrup exists, but it usually contains acetaminophen in my experience, is more expensive, and tastes awful, so Iâd just stick with pills.
A common formulation of DPH is called dimenhydrinate, also known as Dramamine or Gravol. Dimenhydrinate combines DPH with a caffeine-like stimulant, 8-chlorotheophylline. By weight, DMH is about 50% as powerful as DPH by itself. At therapeutic doses, this combination works to counteract the sedating effects of DPH. However, at recreational doses, dimenhydrinate is more cardiotoxic than DPH by itself, and the huge stimulant dose adds to the paranoia, anxiety, and negative physical effects. Avoid using dimenhydrinate for recreational purposes.
- Therapeutic Level: 25 - 100 mg(1-4 Benadryl pills): Probably just going to make you sleepy and cure your allergies temporarily. If you can stay up at the higher end, you might get a tiny bit of a body high, and mental slow-down, kind of like being on a benzo. Not really worth it unless you just wanna sleep. 25-50 mg can potentiate opiates well.
- First Plateau: 100 - 200 mg(4-8 Benadryl pills): This is known as a âfap doseâ. There might be slight music enhancement, and youâll get a bit of that DPH body heaviness, but most people take this amount so their orgasms are enhanced. I really donât recommend doing anything sexual on DPH though. Thereâs several Erowid reports of people having some degree of sexual dysfunction after doing this a few times, with one notable one of a twenty year old developing full-on erectile dysfunction (as in, near-total loss of penis function) after abusing DPH for a year. This is probably due to DPHâs vasoconstrictive properties.
- Second Plateau: 200-300 mg(8-12 Benadryl pills): This is probably the âbestâ range to use at if you donât want full-blown delirium. Music sounds great. Your mouth is going to be soooo fucking dry, and youâre gonna have to piss a lot. However, for a lot of people, they are unable to urinate on DPH, or it at least becomes very difficult. Your body feels like it weighs a thousand pounds, but surprisingly I usually donât fall asleep or even feel sleepy at this level.
You might start seeing slight movement in the corner of your eyes, or occasionally see a spider where there is no spider. Youâll probably experience auditory hallucinations, like a family member calling your name from the distance, or faint footsteps outside your door. Mentally, your short-term memory is going to start to go to hell, and you wonât be able to keep a thought going very long. Some people get closed-eye visuals at this level, which for me are usually short, non-sensical and very abstract visions, which usually are influenced by the music Iâm listening to.
- Second Plateau continued: 300-500 mg(12-20 Benadryl pills): This is the dosage level between the high I described above, and full blown delirium. The âpositiveâ effects will get a bit stronger, especially the confusion, but in my experience and many other /del/vers, the negative effects get much worse, far outweighing the positives. Hallucinations, especially auditory, become much more common, but you still have some ability to differentiate them from reality. Your perfect dosage may be somewhere in this level, especially if youâre a larger person, but for most people this is a shitty dosage.
- Third Plateau/Delirium: 500-700 mg(20-28 pills): Delirium begins to set in, especially past 600 mg, and is almost guaranteed at 700 mg, hence the â700 clubâ. You will probably forget you took anything, and you will have full, lifelike hallucinations. Your parents or the police might come in and harass you for taking drugs, youâll see spiders or snakes all over the place, you might text your friend or grab a remote to change the channel and then see your phone/remote evaporate immediately. Your friends will probably come over and hang out with you for a little bit, probably telling you all about very strange, twisted things. Phantom cigarettes are quite an enjoyable smoke at this dose.
Strangely, emotions are usually dulled quite a bit, so something that would usually terrify you or at least gross you out wonât really have any effect on you. Negative effects-wise, they kinda stop mattering at this point, since your brain is so wonky you probably wonât even pay attention to them. A trip-sitter is highly recommended, and at the very least you should hide your keys and your phone from yourself. Another thing that might be a good idea to hide would be the leftover DPH pills, since you, while tripping, might remember that you wanted to trip on DPH tonight and redose, which could potentially have fatal consequences at this level. You must keep in mind if you plan for this level or any higher levels that once you are delirious, you will have almost no real control over your actions. The experience is very similar to a dream: everything you do will make perfect sense at the time. Unlike a dream, however, you have to deal with any bad decisions that result from your usage.
- Fourth Plateau: 700-1200 mg(28-48 pills): See above. As you dose higher, the trip will get progressively stronger and last longer. Some level of HPPD, at least for the next few days, is pretty much guaranteed at the higher levels(1 gram+). If you have even the slightest care about your health, this is as high as you should go. A trip-sitter is STRONGLY recommended.
- Eiriel: 1.2 grams- 2 grams: Psychedelics have hyperspace. Dissociatives have holes. Deliriants have Eiriel. Eiriel is characterized by almost complete disconnection from reality. Often, people at this level will spend hours walking around, talking to people, swatting phantom bugs, then blink and realize that theyâve just been standing in one spot, and everything that just occurred was a fantasy. YOU SHOULD NOT AIM FOR THIS LEVEL UNLESS YOU HAVE A DEATHWISH. Unlike most other hallucinogen's "breakthrough" doses, this amount of DPH is VERY dangerous and can easily kill you or cause permanent physical and psychological issues.
Hallucinations at this level tend to become hellish, with disturbing, often violent imagery commonly occurring. You may genuinely develop PTSD if you survive a dose of this size. Shadow people, including âThe Hatmanâ are almost always present as well. This level is objectively terrible for your mental and physical health. Seizures are not uncommon, and a high risk of death or serious health complications, including stroke and heart attack is present above 1.5 grams. I personally have dosed this high one time, in a suicide attempt. Iâd guess that I took 1.5 grams at least, I was aiming for 4. I do not remember much of the trip at all, as I believe I spent a lot of it seizing. I have few memories of the trip, which I donât think are entirely fabricated. One is of being in a cave, throwing a torch at a cave demon, and then realizing that I was in my hallway, and I had thrown my phone at my dog. Another is a general feeling of being chased by something with teeth. The most horrific one was seeing my entire family, as well as most of my friends and coworkers, crucified and bleeding on my front lawn and screaming at me for doing this to them. This experience, combined with my previous use of the substance, left me with severe HPPD, worsened my depression, and caused momentary "flashbacks" to the delirious state for months after it happened. If you arenât trying to die, a tripsitter is not just recommended, but NECESSARY.
Hangover: For a lot of people, DPH has a pretty strong hangover. For some, itâs simply feeling very tired the next day. For others, the symptoms can include brain fog, brain zaps, organ pain, blurry vision, headaches, and slight auditory/visual hallucinations, like screams in the distance or some visual drifting.
Combinations: I have not personally tried any of these combinations, AFAIK. I'm using Erowid reports and reports published on this subreddit. Please comment below if you'd like me to add any information about combos.
- Kratom/Opiates: Low doses of DPH (25-50 mg) are known to potentiate opiates a bit. Combining a lower dose of Kratom with DPH seems to mitigate some of the negative effects, such as dysphoria and Restless Legs Syndrome, especially at sub-delirious doses. Use caution, high doses of opiates and deliriants may lead to an increased risk of respiratory depression and death.
- Cannabis: Weed seems to potentiate DPH quite a lot. Both substances cause paranoia, which can reach very uncomfortable levels when combined, and both also dry your mouth/ eyes out. There's a sweet spot, but it differs from person to person. Use sparingly.
- DXM: DXM+DPH is a much-hallowed combination. The substances both potentiate each other a lot and also mitigate the negative effects of one another. Usual dosage is 150/150 to try it out, and 300/300 to have a "full trip". 300/300 will most likely make you quite delirious, comparable to a 600-700 mg DPH trip. Combining lower doses of DPH (~100 mg) with higher doses of DXM seems to mitigate the nausea/itching that DXM can cause while not sending you into full-blown delirium. Use caution, do your research before you try it.
- Psychedelics: Not much information to be found. What little I could seems to show that this is a shitty combo and a waste of psychs. LSD and DPH combined is known as "nightmare flipping", evidently. The visuals will be intensified, but will probably be much uglier and scarier than LSD visuals alone (no surprise there). Confusion will, of course, be increased. It seems that there is nothing much good that can come out of this combination, and it sounds like a highway straight to HPPD and potential psychosis.
- Nicotine: Perhaps of most interest to those who regularly use DPH is nicotine as a possible "trip-killer". Nicotine, being an acetylcholine agonist, seems to partially counteract the effects of a DPH (an acetylcholine antagonist) trip, at least until the dose wears off. The best way to do this, theoretically, would be to take large bong hits of tobacco, use a nicotine patch, or nicotine gum. Cigarettes or vapes would also work, albeit not quite as well. Until you have tried it at a lower dose to see how well it works for you, do not rely on this method as a trip-killer for DPH, especially if it is your first time.
- Benzodiazepines: I have not been able to find much information on this combo. Most of the information I was able to find either suggested that the combination was dangerous due to increased risk of respiratory depression/potential further loss of inhibitions, or that it didn't do much besides further mess with your memory. I would advise against this combination. Benzos will probably not kill the trip like they do with psychedelics, and the idea of somebody barred out and also delirious doesn't sound like it would end well. If you have tried this combination and would like to add your two cents, let me know.
In Conclusion: If you do choose to use DPH, use it
very sparingly. Tolerance to DPH builds rapidly, especially in higher doses, and seems to be very similar to psychedelic tolerance (happens immediately, takes about a week or two to return to baseline). Stay safe yâall.
Hopelijk is dit genoeg voor je
@Madsmoker sinds je zelf blijkbaar niet verder kijkt dan je neus lang is.
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