LSZ (Lysergic acid 2,4-dimethylazetidide)

New LSD analogue hit the market: LSZ


LSZ is an analogue of LSD developed by the team led by David E. Nichols at Purdue University. It was developed as a rigid analogue of LSD with the diethylamide group constrained into an azetidine ring in order to map the binding site at the 5-HT2A receptor. There are three possible stereoisomers around the azetidine ring, with the (S,S)-(+) isomer being the most active, slightly more potent than LSD itself in drug discrimination tests using trained rats.[1]

There have been several unconfirmed reports of lysergic acid 2,4-dimethylazetidide being synthesized in illicit laboratories (most likely by chemist William Leonard Pickard) and distributed on blotter paper or in liquid solution under names such as "diazedine" and "λ".


Lysergic acid 2,4-dimethylazetidide (aka LSZ) belongs to a very small group of serotonergic psychedelics that surpass LSD in potency. Aside from the fact that “diazedine” is a lexical clipping of dimethylazetidine (diazedine<dimethylazetidine), the first paper describing the chemistry and pharmacology of LSZ came out of a laboratory at Purdue University, where Leonard had previously studied under the renowned chemist David Nichols. Though the paper was published after Leonard’s arrest, it is still quite likely he was aware of the preliminary research. When I asked Dr. Nichols whether he thought Pickard may have produced LSZ, he replied, “Leonard knew of our work, of that I am certain.” Rumors of LSZ distributed on blotter paper (purportedly under the name λ) have circulated for years, though there are few confirmed reports of its existence. Of course, the name diazedine is ambiguous and could be referring to just about anything, but I would bet a kilo of benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate that LSZ and diazedine are one and the same.

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*************, I cant say it was amazing but is there any chnce your blotters were old or degraded when were they purchased/researched. Did you get the familiar "lysergic" feeling? I sure did, it ws difantly an acid analogue, just wasn't as good as the real deal.

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Visually mine looked fine. I took them the day I received them after about a week in the mail. Yes, initially I had that feel of a lysergamide, it just never manifested into anything worthwhile.

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all I got from one 150ug blotter was some weird stimulation where I could never get comfortable and a odd half trippy headspace with no visuals. always felt like I was still coming up really. maybe just need to up the dosage? just afraid to bring on heavier unwanted uncomfortable effects.

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25tolife zei:

Wat eigenlijk de LD50 een indicatie zou kunnen geven (ervan uitgaan dat de persoon gezond is) Hij heeft al meerdere ervaringen immers ermee.

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SmartieAndMe zei:

25tolife zei:

Wat eigenlijk de LD50 een indicatie zou kunnen geven (ervan uitgaan dat de persoon gezond is) Hij heeft al meerdere ervaringen immers ermee.

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Wat bedoel je hiermee? Waaruit haal je een indicatie voor LD50? En waar baseer je op dat het vermoedelijk toxischer is?

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