#1
In mijn speurtocht naar de effecten van 2c-b kwam ik dit tegen. Een redelijk recent onderzoek. Commentaar van de auteur nav dit artikel heb ik hieronder vrij vertaald, met de oorspronkelijke tekst erbij. Het artikel geeft aan dat, voor mij, de auteur enig gewicht in de schaal kan leggen, mbt 2c-b's schadelijkheid. (interessant onderzoek, vooral de tabellen met de effecten)
Commentaar:
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Amfetaminen en afgeleide methylenedioxyamphetamines zijn neurotoxisch voor dieren bij hoge doseringen. Dit is een probleem met MDMA, MDA en meth en dit is tientallen jaren geleden al onderzocht en beschreven. 2C-B is gelet op de molecuulstructuur verwant aan mescaline, niet aan MDMA of amfetaminen. En het molecuul mescaline is zeker honderdjaar bekend, er zijn geen studies bekend die aantonen dat mescaline neurotoxisch is in mens of dier. Daarom is het aannemelijk dat 2c-b in potentie niet neurotoxisch is.
Ons team heeft verleden jaar een studie gepubliceerd over de subjectieve effecten van 2c-b op de gebruiker. Het aantal meetingen was klein, maar wij hebben geen nadelige gevolgen of toxische (bewegings-, geheugenproblemen) effecten gevonden, die zouden kunnen duiden op neurotoxische schade.
Oorspronkelijke tekst:
"Amphetamines and ring substituted methylenedioxyamphetamines are known to be neurotoxic in animals in high doses. This is a problem with MDMA, MDA or meth and has been studied and described for decades. 2C-B is structurally related to mescaline, not to MDMA or amphetamines. And mescaline is a molecule known since a century and there are no studies showing neurotoxicity in animals or humans. So it is not likely that 2C-B has significant neurotoxic potential.
Our working team published last year the first study on subjective effects of 2C-B users. The sample was small but we did not find any adverse effects or toxicity ( motor problems, memory complains) suggestive of neurotoxicity."
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Artikel:
4-Bromo-2,5-dimethoxyphenethylamine (2C-B): presence in the recreational drug market in Spain, pattern of use and subjective effects.
Abstract:
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive analogue of mescaline that is becoming increasingly popular as a rave and club drug. We investigated its presence in the illicit drug market in Spain, its pattern of use and profile of subjective effects. Drug material was analysed for 2C-B and information on pattern of use and subjective effects was obtained from recreational users. Scores were statistically compared with previously collected data on psychostimulants (d-amphetamine), entactogens (MDMA) and psychedelics (ayahuasca and Salvia divinorum). The percentage of samples containing 2C-B doubled between 2006 and 2009, evolved from powder to tablet form and showed low falsification rates. Respondents reported taking 2C-B orally in doses of about 20 mg. Subjective effects involved perceptual modifications analogous to those observed after ayahuasca and salvia but absent after amphetamine and MDMA. Pleasure and sociability effects did not differ from those after MDMA and incapacitation was lower than for the psychedelics used as comparators. In conclusion, we found 2C-B is consistently present in the illicit drug market in Spain. While it elicits perceptual modifications that are analogous to other psychedelics, the lower impairment and higher pleasurable effects make it comparable with entactogens.
http://www.scribd.com/doc/78622353/2CB-Caudevilla-2012
http://www.ncbi.nlm.nih.gov/pubmed/22234927
Commentaar:
---------------------------
Amfetaminen en afgeleide methylenedioxyamphetamines zijn neurotoxisch voor dieren bij hoge doseringen. Dit is een probleem met MDMA, MDA en meth en dit is tientallen jaren geleden al onderzocht en beschreven. 2C-B is gelet op de molecuulstructuur verwant aan mescaline, niet aan MDMA of amfetaminen. En het molecuul mescaline is zeker honderdjaar bekend, er zijn geen studies bekend die aantonen dat mescaline neurotoxisch is in mens of dier. Daarom is het aannemelijk dat 2c-b in potentie niet neurotoxisch is.
Ons team heeft verleden jaar een studie gepubliceerd over de subjectieve effecten van 2c-b op de gebruiker. Het aantal meetingen was klein, maar wij hebben geen nadelige gevolgen of toxische (bewegings-, geheugenproblemen) effecten gevonden, die zouden kunnen duiden op neurotoxische schade.
Oorspronkelijke tekst:
"Amphetamines and ring substituted methylenedioxyamphetamines are known to be neurotoxic in animals in high doses. This is a problem with MDMA, MDA or meth and has been studied and described for decades. 2C-B is structurally related to mescaline, not to MDMA or amphetamines. And mescaline is a molecule known since a century and there are no studies showing neurotoxicity in animals or humans. So it is not likely that 2C-B has significant neurotoxic potential.
Our working team published last year the first study on subjective effects of 2C-B users. The sample was small but we did not find any adverse effects or toxicity ( motor problems, memory complains) suggestive of neurotoxicity."
----------------------------
Artikel:
4-Bromo-2,5-dimethoxyphenethylamine (2C-B): presence in the recreational drug market in Spain, pattern of use and subjective effects.
Abstract:
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive analogue of mescaline that is becoming increasingly popular as a rave and club drug. We investigated its presence in the illicit drug market in Spain, its pattern of use and profile of subjective effects. Drug material was analysed for 2C-B and information on pattern of use and subjective effects was obtained from recreational users. Scores were statistically compared with previously collected data on psychostimulants (d-amphetamine), entactogens (MDMA) and psychedelics (ayahuasca and Salvia divinorum). The percentage of samples containing 2C-B doubled between 2006 and 2009, evolved from powder to tablet form and showed low falsification rates. Respondents reported taking 2C-B orally in doses of about 20 mg. Subjective effects involved perceptual modifications analogous to those observed after ayahuasca and salvia but absent after amphetamine and MDMA. Pleasure and sociability effects did not differ from those after MDMA and incapacitation was lower than for the psychedelics used as comparators. In conclusion, we found 2C-B is consistently present in the illicit drug market in Spain. While it elicits perceptual modifications that are analogous to other psychedelics, the lower impairment and higher pleasurable effects make it comparable with entactogens.
http://www.scribd.com/doc/78622353/2CB-Caudevilla-2012
http://www.ncbi.nlm.nih.gov/pubmed/22234927